SlayTheSpire.gg

Debuffs

Bias
Bias
Block Return
Block Return
Choked
Choked
Constricted
Constricted
Corpse Explosion
Corpse Explosion
Draw Reduction
Draw Reduction
Entangled
Entangled
Fasting
Fasting
Hex
Hex
Lock-On
Lock-On
Mark
Mark
No Block
No Block
Wraith Form
Wraith Form
Confused
Confused
Dexterity (Negative)
Dexterity (Negative)
Dexterity Down
Dexterity Down
Focus (Negative)
Focus (Negative)
Frail
Frail
No Draw
No Draw
Poison
Poison
Shackled
Shackled
Slow
Slow
Strength (Negative)
Strength (Negative)
Strength Down
Strength Down
Vulnerable
Vulnerable
Weak
Weak

Debuffs and mitigation

Debuffs like Vulnerable, Weak, and Frail shape turn planning and resource use. Learn how each Slay the Spire debuff stacks, what applies it, and which cards, relics, and potions counter it so you can navigate tough elite and boss patterns with fewer hits.