SlayTheSpire.gg

Monsters

ACT 1

ACT 2

ACT 3

ACT 4

Slay the Spire monsters guide

Learn how to handle Slay the Spire monsters across every act. Hallway fights determine your HP, potion economy, and upgrade cadence before elites and bosses. Knowing intents and common patterns turns scary encounters into routine wins.

Act 1 monsters

Jaw Worm, Louse, Gremlins and Cultists test early Block and consistent damage. Prioritize upgrades that raise breakpoints.

Act 2 monsters

Heavier debuffs and artifact; carry Weak/Vulnerable and plan for scaling threats like Spheric Guardian.

Act 3 monsters

Higher damage floors and disruptive mechanics. Conserve resources for elites and route to campfires smartly.

General tips

  • Use intent icons to plan turn order and target priority.
  • Draft removal for low‑impact Strikes/Defends to hit key damage/block thresholds.
  • Carry flexible potions from the potions list to cover spikes.